Study	Phase	CRC Stage	ctDNA assay
NCT04050345 (TRACC)[@110941]	Prospective Observational	Resected high-risk II-III	Not reported
NCT04068103 NRG-GI005 (COBRA)[@110968]	II/III	Resected stage IIA without high-risk features	LUNAR 1 (Guardant Health
NCT04264702 (BESPOKE)[@110969]	Prospective Observational	Resected high risk II and III	SIGNATERA™
NCT04259944 (PEGASUS)[@110970]	II	Resected MSS III and high-risk II	LUNAR 1 (Guardant Health)
NCT03803553 (SU2C ACT3)	III	Resected III	LUNAR (Guardant Health)
NCT04120701 (CIRCULATE)	III	Resected II	Not reported
ACTRN12617001566325  (DYNAMIC-III)	II/III	Resected III	Safe-SeqS
ACTRN12615000381583 (DYNAMIC-II)	III	Resected II	Safe-SeqS
NCT04084249 (IMPROVE-IT2)	III	Resected high-risk II and III	Not reported
NCT05178576	II	Resected II and III	SIGNATERA™
NCT04089631	III	Resected II	Not reported
NCT05174169 (CIRCULATE-US)	II/III	Resected III	SIGNATERA™
NCT05040568	Ib	II-III, and resected IV	Not reported
NCT03436563	Ib/II	IV	Not reported
NCT04726800 (CITCCA)	Prospective Observational	I-III	Not reported
NCT04920032	II	II-III	SIGNATERA™
NCT02813928 (ADNCirc)	Not Applicable	II-III	Not reported